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microRNA

NOT Open Access | Integrative analysis of microRNA and mRNA expression profiles of monocyte-derived dendritic cells differentiation during experimental cerebral malaria

May 6, 2020 - 15:04 -- NOT Open Access
Author(s): 
Assis PA, Fernandes Durso D, Tostes Gazzinelli R, et al.
Reference: 
J Leukoc Biol. 2020 May 3

Heterogeneity and high plasticity are common features of cells from the mononuclear phagocyte system: monocytes (MOs), macrophages, and dendritic cells (DCs). Upon activation by microbial agents, MO can differentiate into MO‐derived DCs (MODCs). In previous work, we have shown that during acute infection with Plasmodium berghei ANKA (PbA), MODCs become, transiently, the main CD11b+ myeloid population in the spleen (SP) and once recruited to the brain play an important role in the development of experimental cerebral malaria (ECM).

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