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intervention

Evaluation and modeling of direct membrane-feeding assay with Plasmodium vivax to support development of transmission blocking vaccines

July 30, 2020 - 13:29 -- Open Access
Author(s): 
Miura K, Swihart BJ, Fay MP, Kumpitak C, Kiattibutr K, Sattabongkot J, Long CA
Reference: 
Sci Rep. 2020 Jul 28;10(1):12569

Standard and direct membrane-feeding assays (SMFA and DMFA) are fundamental assays to evaluate efficacy of transmission-blocking intervention (TBI) candidates against Plasmodium falciparum and vivax. To compare different candidates precisely, it is crucial to understand the error range of measured activity, usually expressed as percent inhibition in either oocyst intensity (% transmission reducing activity, %TRA), or in prevalence of infected mosquitoes (% transmission blocking activity, %TBA).

Shifting transmission risk for malaria in Africa with climate change: a framework for planning and intervention

May 4, 2020 - 15:27 -- Open Access
Author(s): 
Sadie J. Ryan, Catherine A. Lippi and Fernanda Zermoglio
Reference: 
Malaria Journal 2020 19:170, 1 May 2020

Malaria continues to be a disease of massive burden in Africa, and the public health resources targeted at surveillance, prevention, control, and intervention comprise large outlays of expense. Malaria transmission is largely constrained by the suitability of the climate for Anopheles mosquitoes and Plasmodium parasite development. Thus, as climate changes, shifts in geographic locations suitable for transmission, and differing lengths of seasons of suitability will occur, which will require changes in the types and amounts of resources.

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