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extracellular vesicles

Extracellular vesicles in malaria: an agglomeration of two decades of research

November 23, 2021 - 10:00 -- Open Access
Tosin Opadokun and Petra Rohrbach
Malaria Journal 2021 20:442, 20 November 2021

Malaria is a complex parasitic disease, caused by Plasmodium spp. More than a century after the discovery of malaria parasites, this disease continues to pose a global public health problem and the pathogenesis of the severe forms of malaria remains incompletely understood. Extracellular vesicles (EVs), including exosomes and microvesicles, have been increasingly researched in the field of malaria in a bid to fill these knowledge gaps.

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

June 3, 2020 - 15:52 -- Open Access
Toda H, Diaz-Varela M, Del Portillo HA, et al.
Nat Commun. 2020 Jun 2; 11(1):2761

Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals.

Antibody-Free Labeling of Malaria-Derived Extracellular Vesicles Using Flow Cytometry

May 4, 2020 - 14:06 -- Open Access
Dekel E, Abou Karam P, Ohana-Daniel Y, Biton M, Regev-Rudzki N, Porat Z
Biomedicines. 2020 Apr 27;8(5)

Extracellular vesicles (EVs) are cell-derived membrane-bound structures that are believed to play a major role in intercellular communication by allowing cells to exchange proteins and genetic cargo between them. In particular, pathogens, such as the malaria parasite Plasmodium (P.) falciparum, utilize EVs to promote their growth and to alter their host’s response. Thus, better characterization of these secreted organelles will enhance our understanding of the cellular processes that govern EVs’ biology and pathological functions.

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