The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10621 malaria professionals are enjoying the free benefits of MalariaWorld today

humoral response

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response

October 15, 2020 - 08:50 -- Open Access
Author(s): 
McNamara HA, Idris AH, Cockburn IA, et al.
Reference: 
Cell Host Microbe. 2020 Oct 7;28(4):572-585.e7

Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium falciparum circumsporozoite protein (PfCSP), plateaued after two immunizations in a clinical trial of the radiation-attenuated sporozoite vaccine. To understand the mechanisms limiting vaccine responsiveness, we developed immunoglobulin (Ig)-knockin mice with elevated numbers of PfCSP-binding B cells.

ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS

May 4, 2020 - 14:03 -- Open Access
Author(s): 
Latham LE, Wikenheiser DJ, Stumhofer JS
Reference: 
PLoS Pathog 16(4): e1008527

The co-stimulatory molecule ICOS is associated with the induction and regulation of T helper cell responses, including the differentiation of follicular helper T (Tfh) cells and the formation and maintenance of memory T cells. However, the role of ICOS signaling in secondary immune responses is largely unexplored. Here we show that memory T cell formation and maintenance are influenced by persistent infection with P. chabaudi chabaudi AS infection, as memory T cell numbers decline in wild-type and Icos-/- mice after drug-clearance.

Subscribe to RSS - humoral response