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malaria vaccines

Maintaining immunogenicity of blood stage and sexual stage subunit malaria vaccines when formulated in combination

May 4, 2020 - 14:04 -- Open Access
Author(s): 
Parzych EM, Miura K, Long CA, Burns JM Jr
Reference: 
PLoS ONE 15(4): e0232355

Eradication of Plasmodium falciparum malaria will likely require a multivalent vaccine, but the development of a highly efficacious subunit-based formulation has been challenging. We previously showed that production and immunogenicity of two leading vaccine targets, PfMSP119 (blood-stage) and Pfs25 (sexual stage), could be enhanced upon genetic fusion to merozoite surface protein 8 (PfMSP8). Here, we sought to optimize a Pfs25-based formulation for use in combination with rPfMSP1/8 with the goal of maintaining the immunogenicity of each subunit.

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