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chabaudi AS

ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS

May 4, 2020 - 14:03 -- Open Access
Author(s): 
Latham LE, Wikenheiser DJ, Stumhofer JS
Reference: 
PLoS Pathog 16(4): e1008527

The co-stimulatory molecule ICOS is associated with the induction and regulation of T helper cell responses, including the differentiation of follicular helper T (Tfh) cells and the formation and maintenance of memory T cells. However, the role of ICOS signaling in secondary immune responses is largely unexplored. Here we show that memory T cell formation and maintenance are influenced by persistent infection with P. chabaudi chabaudi AS infection, as memory T cell numbers decline in wild-type and Icos-/- mice after drug-clearance.

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