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Northern Nigeria

Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the region

December 2, 2020 - 07:48 -- Open Access
Author(s): 
Auwal Adamu, Mahmoud Suleiman Jada, Mohammed Nasir Shuaibu, et al.
Reference: 
Malaria Journal 2020 19:439, 30 November 2020

The analysis of single nucleotide polymorphism (SNPs) in drug-resistance associated genes is a commonly used strategy for the surveillance of anti-malarial drug resistance in populations of parasites. The present study was designed and performed to provide genetic epidemiological data of the prevalence of N86Y-Y184F-D1246Y SNPs in Plasmodium falciparum multidrug resistance 1 (pfmdr1) in the malaria hotspot of Northern Nigeria.

Reaching the unreached: effectiveness and satisfaction with community-directed distribution of sulfadoxine-pyrimethamine for preventing malaria in pregnancy in rural South-East, Nigeria

November 10, 2020 - 13:58 -- Open Access
Author(s): 
Ijeoma Nkem Okedo-Alex, Ifeyinwa Chizoba Akamike, Chigozie Jesse Uneke, et al.
Reference: 
Malaria Journal 2020 19:394, 7 November 2020

Innovative community strategies to increase intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) coverage is advocated particularly in rural areas, where health infrastructure is weakest and malaria transmission highest. This study involved proof-of-concept implementation research to determine satisfaction with and effectiveness of community-directed distribution of IPTp-SP on uptake among pregnant women in Ebonyi State, Nigeria.

Exploring the Mechanisms of Multiple Insecticide Resistance in a Highly Plasmodium-Infected Malaria Vector Anopheles funestus Sensu Stricto from Sahel of Northern Nigeria

April 27, 2020 - 13:20 -- Open Access
Author(s): 
Ibrahim SS, Mukhtar MM, Irving H, Riveron JM, Fadel AN, Tchapga W, Hearn J, Muhammad A, Sarkinfada F, Wondji CS
Reference: 
Genes (Basel). 2020 Apr 22;11(4). pii: E454

The Nigerian Government is scaling up the distribution of insecticide-treated bed nets for malaria control, but the lack of surveillance data, especially in the Sudan/Sahel region of the country, may hinder targeting priority populations. Here, the vectorial role and insecticide resistance profile of a population of a major malaria vector Anopheles funestus sensu stricto from Sahel of Nigeria was characterised.

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