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antiplasmodial alkaloids

NOT Open Access | Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

October 28, 2020 - 09:55 -- NOT Open Access
Author(s): 
Kleks G, Holland DC, Kennedy EK, Avery VM, Carroll AR
Reference: 
J Nat Prod. 2020 Oct 26

An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi resulted in the isolation of six new brominated alkaloids, convolutamines K and L (1 and 2), volutamides F-H (3-5), and 2,5-dibromo-1-methyl-1H-indole-3-carbaldehyde (6).

Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud.

December 4, 2017 - 15:25 -- Open Access
Author(s): 
Namki Cho, Yongle Du, Ana Lisa Valenciano, Maria L. Fernández-Murga, Michael Goetz, Jason Clement, Maria B. Cassera, David G.I. Kingston
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 28, Issue 1, 1 January 2018, Pages 40-42

A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane alkaloids 2–4 and the two lycorane alkaloids 5–6.

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