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20-hydroxyecdysone

JNK signaling regulates oviposition in the malaria vector Anopheles gambiae

September 2, 2020 - 11:52 -- Open Access
Author(s): 
Peirce MJ, Mitchell SN, Kakani EG, Scarpelli P, South A, Shaw WR, Werling KL, Gabrieli P, Marcenac P, Bordoni M, Talesa V, Catteruccia F
Reference: 
Sci Rep. 2020 Sep 1;10(1):14344

The reproductive fitness of the Anopheles gambiae mosquito represents a promising target to prevent malaria transmission. The ecdysteroid hormone 20-hydroxyecdysone (20E), transferred from male to female during copulation, is key to An. gambiae reproductive success as it licenses females to oviposit eggs developed after blood feeding. Here we show that 20E-triggered oviposition in these mosquitoes is regulated by the stress- and immune-responsive c-Jun N-terminal kinase (JNK).

20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae

April 20, 2020 - 08:59 -- Open Access
Author(s): 
Reynolds RA, Kwon H, Smith RC
Reference: 
mSphere. 2020 Apr 15;5(2). pii: e00983-19

Blood feeding is an integral behavior of mosquitoes to acquire nutritional resources needed for reproduction. This requirement also enables mosquitoes to serve as efficient vectors to acquire and potentially transmit a multitude of mosquito-borne diseases, most notably malaria. Recent studies suggest that mosquito immunity is stimulated following a blood meal, independent of infection status.

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