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epitope‐specific memory cells

NOT Open Access | Main B‐cell epitopes of PvAMA‐1 and PvMSP‐9 are targeted by naturally acquired antibodies and epitope‐specific memory cells in acute and convalescent phases of vivax malaria

April 20, 2020 - 08:54 -- NOT Open Access
Roberta Reis Soares, Clovis Ryuichi Nakaie, Rodrigo Nunes Rodrigues‐da‐Silva, Rogério Lauria da Silva, Josué da Costa Lima‐Junior, Kézia Katiani Gorza Scopel
Parasite Immunology, Volume42, Issue5, May 2020 e12705

Although antibodies are considered critical for malaria protection, little is known about the mechanisms/factors that maintain humoral immunity, especially regarding the induction and maintenance of memory B cells over time. In Brazilian endemic areas, this is the first time that the profile of antibody responses and the occurrence of antigen‐specific memory B cells (MBC) against P vivax were investigated during acute malaria and up to six months after parasite clearance.

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