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epitope‐specific memory cells

NOT Open Access | Main B‐cell epitopes of PvAMA‐1 and PvMSP‐9 are targeted by naturally acquired antibodies and epitope‐specific memory cells in acute and convalescent phases of vivax malaria

April 20, 2020 - 08:54 -- NOT Open Access
Author(s): 
Roberta Reis Soares, Clovis Ryuichi Nakaie, Rodrigo Nunes Rodrigues‐da‐Silva, Rogério Lauria da Silva, Josué da Costa Lima‐Junior, Kézia Katiani Gorza Scopel
Reference: 
Parasite Immunology, Volume42, Issue5, May 2020 e12705

Although antibodies are considered critical for malaria protection, little is known about the mechanisms/factors that maintain humoral immunity, especially regarding the induction and maintenance of memory B cells over time. In Brazilian endemic areas, this is the first time that the profile of antibody responses and the occurrence of antigen‐specific memory B cells (MBC) against P vivax were investigated during acute malaria and up to six months after parasite clearance.

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