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asymptomatic malaria

Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya

July 28, 2020 - 14:42 -- Open Access
Author(s): 
Lawrence S. Redmond, Martin D. Ogwang, Sam M. Mbulaiteye, et al.
Reference: 
Malaria Journal 2020 19:239, 28 July 2020

Endemic Burkitt lymphoma (eBL) is an aggressive B cell non-Hodgkin lymphoma associated with antigenic stimulation from Plasmodium falciparum malaria. Whether eBL risk is related to malaria parasite density is unknown. To address this issue, children with eBL, asymptomatic and clinical malaria, as a surrogate of malaria parasite density, were assessed.

Point prevalence of asymptomatic Plasmodium infection and the comparison of microscopy, rapid diagnostic test and nested PCR for the diagnosis of asymptomatic malaria among children under 5 years in Ghana

July 28, 2020 - 14:06 -- Open Access
Author(s): 
Okyere B, Owusu-Ofori A, Dickerson T, et al.
Reference: 
PLoS ONE 15(7): e0232874

Plasmodium infection among children is a serious public health problem. Asymptomatic malaria infection among humans serves as a significant reservoir for transmitting Plasmodium to uninfected Anopheles mosquitoes, fueling malaria endemicity and asymptomatic malaria may progress to clinical malaria. Therefore, prompt and accurate diagnosis of malaria infection is crucial for the management and control of malaria, especially in endemic areas. This study assessed the point prevalence of asymptomatic malaria infection and evaluated the performance of malaria Rapid Diagnostic Tests (RDT), light microscopy and nested PCR (nPCR) for the diagnosis of asymptomatic malaria infection in a paediatric population in the Atwima Nwabiagya North district, Ghana.

NOT Open Access | Prevalence of Asymptomatic and/or Low-Density Malaria Infection among High-Risk Groups in Peninsular Malaysia

July 7, 2020 - 12:50 -- NOT Open Access
Author(s): 
Noordin NR, Lee PY, Mohd Bukhari FD, Fong MY, Abdul Hamid MH, Jelip J, Mudin RN, Lau YL
Reference: 
Am J Trop Med Hyg. 2020 Jul 6

Asymptomatic and/or low-density malaria infection has been acknowledged as an obstacle to achieving a malaria-free country. This study aimed to determine the prevalence of asymptomatic and/or low-density malaria infection in previously reported malarious localities using nested PCR in four states, namely, Johor, Pahang, Kelantan, and Selangor, between June 2019 and January 2020. Blood samples (n = 585) were collected and were extracted using a QIAamp blood kit.

Haematological Parameters and Spleen Rate of Asymptomatic and Malaria Negative Children in Edo South District, Nigeria

June 29, 2020 - 16:25 -- Open Access
Author(s): 
Nwaneri D, Oladipo O, Ifebi E, Oviawe O, Asemota O, Ogboghodo B, Israel-Aina Y, Sadoh A
Reference: 
Ann Glob Health. 2020 Jun 17; 86(1):62

Malaria is commonly associated with alteration in haematologic cells of infected individuals in both the acute uncomplicated and severe phases. Whether this alteration occurs in the asymptomatic phase of the disease is still being investigated.

Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria

May 12, 2020 - 16:39 -- Open Access
Author(s): 
Louis Regis Dossou-Yovo, Francine Ntoumi, Felix Koukouikila-Koussounda, Jeannhey Christevy Vouvoungui, Ayodele Adedoja, David Nderu, Thirumalaisamy P. Velavan and Arsène Lenga
Reference: 
Malaria Journal 2020 19:178, 8 May 2020

Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and eradication programmes. Plasmodium falciparum multiple drug resistance-1 gene (Pfmdr1) N86Y mutation is associated with reduced susceptibility to lumefantrine. This study assessed the prevalence of Pfmdr1 N86Y in Brazzaville, Republic of Congo.

Prevalence and Correlates of Asymptomatic Malaria and Anemia on First Antenatal Care Visit among Pregnant Women in Southeast, Tanzania

May 6, 2020 - 15:54 -- Open Access
Author(s): 
Mlugu EM, Minzi O, Kamuhabwa AAR, Aklillu E
Reference: 
Int J Environ Res Public Health. 2020 Apr 30;17(9), pii: E3123.

Asymptomatic malaria and anemia during pregnancy increase the risk of negative birth outcomes. This cross-sectional study investigated the prevalence and correlates of asymptomatic malaria and anemia during first antenatal care (ANC) visit among pregnant women in a rural district, Tanzania. HIV-uninfected pregnant women without symptoms of malaria (n = 819) attending their first ANC at Kibiti Health Centre were enrolled from February 2017 to February 2018.

High levels of imported asymptomatic malaria but limited local transmission in KwaZulu-Natal, a South African malaria-endemic province nearing malaria elimination

April 18, 2020 - 13:53 -- Open Access
Author(s): 
Jaishree Raman, Laura Gast, Devanand Moonasar, et al.
Reference: 
Malaria Journal 2020 19:152, 15 April 2020

KwaZulu-Natal, one of South Africa’s three malaria endemic provinces, is nearing malaria elimination, reporting fewer than 100 locally-acquired cases annually since 2010. Despite sustained implementation of essential interventions, including annual indoor residual spraying, prompt case detection using malaria rapid diagnostics tests and treatment with effective artemisinin-based combination therapy, low-level focal transmission persists in the province. This malaria prevalence and entomological survey was therefore undertaken to identify the drivers of this residual transmission.

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