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amplificating Th17

Plasmodium yoelii 17XL infection modified maturation and function of dendritic cells by skewing Tregs and amplificating Th17

April 10, 2020 - 16:44 -- Open Access
Author(s): 
Chen G, Du JW, Nie Q, Du YT, Liu SC, Liu DH, Zhang HM, Wang FF
Reference: 
BMC Infect Dis. 2020 Apr 6;20(1):266

Emerging data has suggested that Tregs, Th17, Th1 and Th2 are correlated with early immune mechanisms by controlling Plasmodium infection. Plasmodium infection appeared to impair the antigen presentation and maturation of DCs, leading to attenuation of specific cellular immune response ultimately. Hence, in this study, we aim to evaluate the relevance between DCs and Tregs/Th17 populations in the process and outcomes of infection with Plasmodium yoelii 17XL (P.y17XL).

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