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multi-functional antibodies

Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial

April 6, 2020 - 15:34 -- Open Access
Author(s): 
Kurtovic L, Atre T, Beeson JG, et al.
Reference: 
J Infect Dis. 2020 Mar 31. pii: jiaa144

RTS,S is the leading malaria vaccine candidate, but only confers partial efficacy against malaria in children. RTS,S is based on the major Plasmodium falciparum sporozoite surface antigen, circumsporozoite protein (CSP). The induction of anti-CSP antibodies is important for protection, however, it is unclear how these protective antibodies function.

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