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Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites

April 6, 2020 - 15:29 -- Open Access
de Sousa ACC, Maepa K, Combrinck JM, Egan TJ
Molecules. 2020 Mar 29;25(7). pii: E1571

With the continued loss of antimalarials to resistance, drug repositioning may have a role in maximising efficiency and accelerating the discovery of new antimalarial drugs. Bayesian statistics was previously used as a tool to virtually screen USFDA approved drugs for predicted β-haematin (synthetic haemozoin) inhibition and in vitro antimalarial activity.

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