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apical membrane antigen-1

Low genetic diversity and strong immunogenicity within the apical membrane antigen-1 of Plasmodium ovale spp. imported from Africa to China

June 23, 2020 - 16:10 -- Open Access
Author(s): 
Lei Y, Shen F, Cheng Y, et al.
Reference: 
Acta Trop. 2020 Jun 17:105591

Malaria is still an important challenge for global public health because of its extensive mortality and morbidity. Plasmodium ovale is mainly distributed in tropical regions of Africa and Asia. it includes two distinct ovale malaria species, which are P. ovale curtisi and P. ovale wallikeri. Apical membrane antigen-1 (AMA-1) is an asexual blood-stage protein which is essential for Plasmodium. Thus far, no study on gene polymorphism and immunogenicity of P. ovale AMA-1 (PoAMA-1) has been conducted. Amplified poama1 gene products from 14 P ovale curtisi samples and 12 P ovale wallikeri samples imported from Africa to Jiangsu Province, China were sequenced and their polymorphisms were analyzed.

Natural selection and genetic diversity of domain I of Plasmodium falciparum apical membrane antigen-1 on Bioko Island

September 23, 2019 - 14:34 -- Open Access
Author(s): 
Ya-Nan Wang, Min Lin, Hai-Bin Chen, et al.
Reference: 
Malaria Journal 2019 18:317, 18 September 2019

Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a promising candidate antigen for a blood-stage malaria vaccine. However, antigenic variation and diversity of PfAMA-1 are still major problems to design a universal malaria vaccine based on this antigen, especially against domain I (DI). Detail understanding of the PfAMA-1 gene polymorphism can provide useful information on this potential vaccine component. Here, general characteristics of genetic structure and the effect of natural selection of DIs among Bioko P. falciparum isolates were analysed.

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