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young children

Risk of malaria in young children after periconceptional iron supplementation

November 28, 2020 - 15:56 -- Open Access
Gies S, Roberts SA, Diallo S, Lompo OM, Tinto H, Brabin BJ
Matern Child Nutr. 2020 Nov 25:e13106

This study in Burkina Faso investigated whether offspring of young mothers who had received weekly periconceptional iron supplementation in a randomised controlled trial were at increased risk of malaria. A child safety survey was undertaken in the peak month of malaria transmission towards the end of the trial to assess child iron biomarkers, nutritional status, anaemia and malaria outcomes. Antenatal iron biomarkers, preterm birth, fetal growth restriction and placental pathology for malaria and chorioamnionitis were assessed.

NOT Open Access | The preclinical discovery and development of rectal artesunate for the treatment of malaria in young children; review of evidence

September 15, 2020 - 14:35 -- NOT Open Access
de Carvalho LP, Kreidenweiss A, Held J
Expert Opin Drug Discov. 2020 Sep 14:1-10

Plasmodium falciparum, the deadliest malaria parasite, kills hundreds of thousands of people per year, mainly young children in Sub-Saharan Africa. Artesunate suppositories are recommended as pre-referral malaria treatment in remote endemic areas for severely ill children to prevent progression of the disease and to provide extra time for patients until the definitive severe malaria treatment can be administered.

NOT Open Access | Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses

July 27, 2020 - 12:31 -- NOT Open Access
Park S, Nixon CE, Miller O, Choi NK, Kurtis JD, Friedman JF, Michelow IC
J Infect Dis. 2020 Jul 23; 222(4):538-550

Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy.

COVID-19 and the impact on malaria

June 2, 2020 - 09:36 -- Open Access
Chiodini J
Travel Med Infect Dis. 2020 May 29:101758

As COVID -19 continues to dominate the health and political agendas in so many countries around the world, so does its devastating impact on other diseases become apparent. Malaria is just one of these.

The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018

May 21, 2020 - 06:46 -- Open Access
Kamya MR, Kakuru A, Dorsey G, et al.
Am J Trop Med Hyg. 2020 May 18

There is limited evidence on whether malaria elimination is feasible in high-transmission areas of Africa. Between 2007 and 2018, we measured the impact of malaria control interventions in young children enrolled in three clinical trials and two observational studies in Tororo, Uganda, a historically high-transmission area. Data were pooled from children aged 0.5–2 years.

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