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nonpeptidyl molecule

A Nonpeptidyl Molecule Modulates Apoptosis-like Cell Death by Inhibiting P.falciparum Metacapase-2

March 24, 2020 - 12:31 -- Open Access
Author(s): 
Kumari V, Sankar S, Prasad KM, Kashif M, Kalia I, Rai R, Singh AP, Pandey KC
Reference: 
Biochem J. 2020 Mar 23. pii: BCJ20200050

Metacaspases are novel cysteine proteases found in apicomplexan whose function is poorly understood. Our earlier studies on Plasmodium falciparum metacaspase-2 (PfMCA-2) revealed that the caspase inhibitor, Z-FA-FMK efficiently inhibited PfMCA-2 activity and, expression, and significantly blocked in vitro progression of the parasite developmental cycle via apoptosis-like parasite death.

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