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Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults

September 15, 2020 - 10:09 -- Open Access
Author(s): 
Healy SA, Murphy SC, Duffy PE, et al.
Reference: 
Clin Infect Dis. 2020 Sep 12;71(6):1481-1490

Chemoprophylaxis vaccination with sporozoites (CVac) with chloroquine induces protection against a homologous Plasmodium falciparum sporozoite (PfSPZ) challenge, but whether blood-stage parasite exposure is required for protection remains unclear. Chloroquine suppresses and clears blood-stage parasitemia, while other antimalarial drugs, such as primaquine, act against liver-stage parasites. Here, we evaluated CVac regimens using primaquine and/or chloroquine as the partner drug to discern whether blood-stage parasite exposure impacts protection against homologous controlled human malaria infection.

NOT Open Access | Clinical Impact of Malaria Rapid Diagnostic Testing at a US Children's Hospital

July 20, 2020 - 08:09 -- NOT Open Access
Author(s): 
Enane LA, Sullivan KV, Spyridakis E, Feemster KA
Reference: 
J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):298-304

Children who develop malaria after returning to a setting in which the disease is not endemic are at high risk for critical delays in diagnosis and initiation of antimalarial therapy. We assessed the clinical impact of the implementation of malaria rapid diagnostic testing (RDT) on the management of children with malaria at an urban US children’s hospital that serves a large immigrant population.

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