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hotspots

Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite Invasion

July 7, 2020 - 13:48 -- Open Access
Author(s): 
Patarroyo MA, Molina-Franky J, Gómez M, Arévalo-Pinzón G, Patarroyo ME
Reference: 
Int J Mol Sci. 2020 Jul 2;21(13):E4729

Protein-protein interactions (IPP) play an essential role in practically all biological processes, including those related to microorganism invasion of their host cells. It has been found that a broad repertoire of receptor-ligand interactions takes place in the binding interphase with host cells in malaria, these being vital interactions for successful parasite invasion. Several trials have been conducted for elucidating the molecular interface of interactions between some Plasmodium falciparum and Plasmodium vivax antigens with receptors on erythrocytes and/or reticulocytes.

Active Case Finding for Malaria: A 3-Year National Evaluation of Optimal Approaches to Detect Infections and Hotspots Through Reactive Case Detection in the Low-transmission Setting of Eswatini

March 20, 2020 - 12:33 -- Open Access
Author(s): 
Hsiang MS, Ntshalintshali N, Greenhouse B, et al.
Reference: 
Clin Infect Dis. 2020 Mar 17;70(7):1316-1325

Reactive case detection (RACD) is a widely practiced malaria elimination intervention whereby close contacts of index cases receive malaria testing to inform treatment and other interventions. However, the optimal diagnostic and operational approaches for this resource-intensive strategy are not clear.

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