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chalcone hybrids

Not Open Access | Chalcone hybrids and their antimalarial activity

April 6, 2020 - 14:43 -- NOT Open Access
Cheng P, Yang L, Huang X, Wang X, Gong M
Arch Pharm (Weinheim). 2020 Apr;353(4):e1900350

Malaria, one of the most striking, re‐emerging infectious diseases caused by the genus Plasmodium, places a huge burden on global healthcare systems. A major challenge in the control and eradication of malaria is the continuous emergence of increasingly widespread drug‐resistant malaria, creating an urgent need to develop novel antimalarial agents.

NOT Open Access | Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review

March 19, 2020 - 09:07 -- NOT Open Access
Qin HL, Zhang ZW, Lekkala R, Alsulami H, Rakesh KP
Eur J Med Chem. 2020 Mar 9; 193:112215

Malaria remains a serious worldwide health danger and massive economic trouble to disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide. The emergence of fighting of the Plasmodium parasite against the first-line antimalarial drugs has fueled research attention in the way of designing new scaffolds as well as strategies to counter the drug resistance.

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