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kelch 13

NOT Open Access | Identification of Single-Nucleotide Polymorphisms in the Mitochondrial Genome and Kelch 13 Gene of Plasmodium falciparum in Different Geographical Populations

July 21, 2021 - 17:09 -- NOT Open Access
Author(s): 
Nydahl TK, Ahorhorlu SY, Alifrangis M, et al.
Reference: 
Am J Trop Med Hyg. 2021 Jul 16:tpmd210320

The emergence of artemisinin-resistant Plasmodium falciparum parasites in Southeast Asia threatens malaria control and elimination. The interconnectedness of parasite populations may be essential to monitor the spread of resistance. Combining a published barcoding system of geographically restricted single-nucleotide polymorphisms (SNPs), mainly mitochondria of P. falciparum with SNPs in the K13 artemisinin resistance marker, could elucidate the parasite population structure and provide insight regarding the spread of drug resistance.

NOT Open Access | Molecular Detection of Mutations in the Propeller Domain of Kelch 13 and pfmdr1 Copy Number Variation in Plasmodium falciparum Isolates from Thailand Collected from 2002 to 2007

July 21, 2021 - 17:03 -- NOT Open Access
Author(s): 
Chaisatit C, Sai-Ngam P, Thaloengsok S, Sriwichai S, Jongsakul K, Fukuda M, Spring M, Wojnarski M, Waters N, Lertsethtakarn P, Vesely BA
Reference: 
Am J Trop Med Hyg. 2021 Jul 16:tpmd210303

We determined the prevalence of Kelch 13 mutations and pfmdr1 copy number in samples collected from the Thailand-Myanmar border, the Thailand-Cambodia border, and southern Thailand from 2002 to 2007.

Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) protocol

March 19, 2020 - 08:39 -- Open Access
Author(s): 
L'Episcopia M, Kelley J, Patel D, Schmedes S, Ravishankar S, Menegon M, Perrotti E, Nurahmed AM, Talha AA, Nour BY, Lucchi N, Severini C, Talundzic E
Reference: 
Parasit Vectors. 2020 Mar 14; 13(1):137

Routine molecular surveillance for imported drug-resistant malaria parasites to the USA and European Union is an important public health activity. The obtained molecular data are used to help keep chemoprophylaxis and treatment guidelines up to date for persons traveling to malaria endemic countries. Recent advances in next-generation sequencing (NGS) technologies provide a new and effective way of tracking malaria drug-resistant parasites.

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