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randomised clinical trial

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

March 19, 2020 - 08:33 -- Open Access
Author(s): 
van der Pluijm RW, Tripura R, Dondorp AM, et al.
Reference: 
Lancet. 2020 Mar 11. pii: S0140-6736(20)30552-3

Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance.

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