The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10820 malaria professionals are enjoying the free benefits of MalariaWorld today

African children

Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children

June 9, 2020 - 11:33 -- Open Access
Author(s): 
Bundi CK, Nalwoga A, Atkinson SH, et al.
Reference: 
Clin Infect Dis. 2020 Jun 7:ciaa728

Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on antibody responses to Plasmodium falciparum malaria.

Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children

May 7, 2020 - 13:24 -- Open Access
Author(s): 
Ding J, Coldiron ME, Assao B, Guindo O, Blessborn D, Winterberg M, Grais RF, Koscalova A, Langendorf C, Tarning J
Reference: 
Clin Pharmacol Ther. 2020 May;107(5):1179-1188

Poor adherence to seasonal malaria chemoprevention (SMC) might affect the protective effectiveness of SMC. Here, we evaluated the population pharmacokinetic properties of amodiaquine and its active metabolite, desethylamodiaquine, in children receiving SMC under directly observed ideal conditions (n = 136), and the adherence of SMC at an implementation phase in children participating in a case‐control study to evaluate SMC effectiveness (n = 869).

NOT Open Access | Effect of Adding Azithromycin to the Antimalarials used for Seasonal Malaria Chemoprevention on the Nutritional Status of African Children

March 18, 2020 - 14:37 -- NOT Open Access
Author(s): 
Gore-Langton GR, Cairns M, Ouedraogo JB, et al.
Reference: 
Trop Med Int Health. 2020 Mar 12

Mass administration of azithromycin has reduced mortality in children in sub‐Saharan Africa but its mode of action is not well characterised. A recent trial found that azithromycin given alongside seasonal malaria chemoprevention was not associated with a reduction in mortality or hospital admissions in young children. We investigated the effect of azithromycin on the nutritional status of children enrolled in this study.

Subscribe to RSS - African children