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MiRNA-146a

NOT Open Access | MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India

March 9, 2020 - 14:35 -- NOT Open Access
Author(s): 
van Loon W, Gai PP, Kulkarni SS, Rasalkar R, Siegert K, Wedam J, Boloor A, Baliga S, Kumar A, Jain A, Mahabala C, Shenoy D, Devi R, Gai P, Mockenhaupt FP
Reference: 
Am J Trop Med Hyg. 2020 Mar 2

Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. Plasmodium vivax malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%).

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