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blood stage

A genetically hmgb2 attenuated blood stage P. berghei induces crossed-long live protection

May 12, 2020 - 16:47 -- Open Access
Author(s): 
Briquet S, Lawson-Hogban N, Peronet R, Mécheri S, Vaquero C
Reference: 
PLoS ONE 15(5): e0232183

Due to the lack of efficiency to control malaria elicited by sub-unit vaccine preparations, vaccination with live-attenuated Plasmodium parasite as reported 70 years ago with irradiated sporozoites regained recently a significant interest. The complex life cycle of the parasite and the different stages of development between mammal host and anopheles do not help to propose an easy vaccine strategy.

Maintaining immunogenicity of blood stage and sexual stage subunit malaria vaccines when formulated in combination

May 4, 2020 - 14:04 -- Open Access
Author(s): 
Parzych EM, Miura K, Long CA, Burns JM Jr
Reference: 
PLoS ONE 15(4): e0232355

Eradication of Plasmodium falciparum malaria will likely require a multivalent vaccine, but the development of a highly efficacious subunit-based formulation has been challenging. We previously showed that production and immunogenicity of two leading vaccine targets, PfMSP119 (blood-stage) and Pfs25 (sexual stage), could be enhanced upon genetic fusion to merozoite surface protein 8 (PfMSP8). Here, we sought to optimize a Pfs25-based formulation for use in combination with rPfMSP1/8 with the goal of maintaining the immunogenicity of each subunit.

Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

March 10, 2020 - 16:21 -- Open Access
Author(s): 
Dans MG, Weiss GE, Wilson DW, Sleebs BE, Crabb BS, de Koning-Ward TF, Gilson PR
Reference: 
Int J Parasitol. 2020 Mar 2. pii: S0020-7519(20)30033-3

With emerging resistance to frontline treatments, it is vital that new drugs are identified to target Plasmodium falciparum. One of the most critical processes during the parasites’ asexual lifecycle is the invasion and subsequent egress of red blood cells (RBCs). Many unique parasite ligands, receptors and enzymes are employed during egress and invasion that are essential for parasite proliferation and survival, therefore making these processes druggable targets.

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