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cancer

Malaria and Cancer: a critical review on the established associations and new perspectives

May 19, 2021 - 13:28 -- Open Access
Author(s): 
Ellis T, Eze E, Raimi-Abraham BT
Reference: 
Infect Agent Cancer. 2021 May 13;16(1):33

Cancer and malaria both have high incidence rates and are leading causes of mortality worldwide, especially in low and middle-income countries with reduced access to the quality healthcare. The objective of this critical review was to summarize key associations and new perspectives between the two diseases as is reported in existing literature.

An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer

December 15, 2020 - 15:57 -- Open Access
Author(s): 
Toledo AG, Pihl J, Spliid CB, Persson A, Nilsson J, Pereira MA, Gustavsson T, Choudhary S, Zarni Oo H, Black PC, Daugaard M, Esko JD, Larson G, Salanti A, Clausen TM
Reference: 
Glycobiology. 2020 Dec 9;30(12):989-1002

Chondroitin sulfate (CS) is the placental receptor for the VAR2CSA malaria protein, expressed at the surface of infected erythrocytes during Plasmodium falciparum infection. Infected cells adhere to syncytiotrophoblasts or get trapped within the intervillous space by binding to a determinant in a 4-O-sulfated CS chains. However, the exact structure of these glycan sequences remains unclear.

Malaria and risk of lymphoid neoplasms and other cancer: a nationwide population-based cohort study

November 4, 2020 - 09:30 -- Open Access
Author(s): 
Wyss K, Granath F, Wångdahl A, Djärv T, Fored M, Naucler P, Färnert A
Reference: 
BMC Med. 2020 Oct 30;18(1):296

Malaria is associated with Burkitt lymphoma among children in Sub-Saharan Africa. No longitudinal studies have assessed the long-term risk of other lymphoma or cancer overall. Here, we investigated the risk of lymphoid neoplasms and other cancer after malaria.

DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models

June 1, 2020 - 16:20 -- Open Access
Author(s): 
Huang HW, Bow YD, Wang CY, Chen YC, Fu PR, Chang KF, Wang TW, Tseng CH, Chen YL, Chiu CC
Reference: 
Cancers (Basel). 2020 May 25; 12(5):E1348

Lung cancer is one of the deadliest cancers worldwide due to chemoresistance in patients with late-stage disease. Quinoline derivatives show biological activity against HIV, malaria, bacteriuria, and cancer. DFIQ is a novel synthetic quinoline derivative that induces cell death in both in vitro and in vivo zebrafish xenograft models. DFIQ induced cell death, including apoptosis, and the IC50 values were 4.16 and 2.31 μM at 24 and 48 h, respectively.

NOT Open Access | An Affinity-Chromatography and Glycoproteomics Workflow to Profile the Chondroitin Sulfate Proteoglycans that interact with malarial VAR2CSA in the Placenta and in Cancer

April 29, 2020 - 05:31 -- NOT Open Access
Tags: 
Author(s): 
Toledo AG, Pihl J, Clausen TM, et al.
Reference: 
Glycobiology. 2020 Apr 27. pii: cwaa039

Chondroitin sulfate (CS) is the placental receptor for the VAR2CSA malaria protein, expressed at the surface of infected erythrocytes during Plasmodium falciparum infection. Infected cells adhere to syncytiotrophoblasts or get trapped within the intervillous space by binding to a determinant in a 4-O-sulfated CS chains. However, the exact structure of these glycan sequences remains unclear.

Endemic Burkitt lymphoma - an aggressive childhood cancer linked to Plasmodium falciparum exposure, but not to exposure to other malaria parasites

March 10, 2020 - 16:16 -- Open Access
Author(s): 
Quintana MDP, Smith-Togobo C, Moormann A, Hviid L
Reference: 
APMIS. 2020 Mar 4. doi: 10.1111/apm.13018

Burkitt lymphoma (BL) is an aggressive non‐Hodgkin lymphoma. The prevalence of BL is ten‐fold higher in areas with stable transmission of Plasmodium falciparum malaria, where it is the most common childhood cancer, and is referred to as endemic BL (eBL). In addition to its association with exposure to P. falciparum infection, eBL is strongly associated with Epstein–Barr virus (EBV) infection (>90%).

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