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NOT Open Access | Chemotherapeutic and prophylactic antimalarial drugs induce cell death through mitochondrial-mediated apoptosis in murine models

January 6, 2021 - 13:06 -- NOT Open Access
Olanlokun JO, Balogun FA, Olorunsogo OO
Drug Chem Toxicol. 2021 Jan;44(1):47-57

Malaria is a parasitic disease that has defied many treatment plans. This study was carried out to investigate the host mitochondrial response to malarial infection and selected antimalarial chemotherapy using murine models. The effects of artesunate (ART) and proguanil (PRG) on mitochondrial Permeability Transition (mPT), mitochondrial ATPase (mATPase), level of malondialdehyde (MDA) and activities of antioxidant enzymes; catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), Xanthine oxidase (XO), glutathione S-transferase (GST) and reduced glutathione (GSH) were estimated in Plasmodium berghei-infected mice treated with ART and PRG.

Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries

December 29, 2020 - 15:52 -- Open Access
Quashie NB, Duah-Quashie NO
J Trop Pediatr. 2020 Dec 27:fmaa089

Based on reports of parasite resistance and on World Health Organization recommendation, chloroquine was replaced with the artemisinin-based combination therapies (ACTs) as the first choice of drugs for the treatment of uncomplicated malaria. Disuse of chloroquine led to restoration of drug-sensitive parasite to some extent in certain countries. Ever since chloroquine and hydroxychloroquine were touted as potential treatment for coronavirus disease 2019 (COVID-19), there has been a dramatic surge in demand for the drugs.

NOT Open Access | The Role of Clinical Pharmacology in Chemotherapy of Multidrug-Resistant Plasmodium falciparum

March 3, 2020 - 13:13 -- NOT Open Access
Karbwang J, Na-Bangchang K
J Clin Pharmacol. 2020 Feb 27

Malaria remains one of the major global public health problems due to the emergence and spread of multidrug‐resistant Plasmodium falciparum. In recent years, clinical pharmacology has significantly contributed to the optimal dosing regimens of antimalarial drugs.

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