Laboratory and epidemiologic studies have clarified how persons born with malaria-resistant red blood cells (RBCs)–like group-O, sickle-trait, and C-trait RBCs–are protected against death or severe disease due to Plasmodium falciparum (Pf) infection. Compared to malaria-promoting RBCs–like non-O or hemoglobin-AA RBCs–inborn RBC protection against severe Pf malaria can be profound: up to 10-fold greater.
ABO blood group
Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM are increased in anemic patients with acute vivax malaria.