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infection-cure cycles

NOT Open Access | Plasmodium infection-cure cycles induce modulation of conventional dendritic cells

March 2, 2020 - 15:15 -- NOT Open Access
Adachi R, Tamura T
Microbiol Immunol. 2020 Feb 25

Malaria is one of the most widespread human infectious diseases worldwide and a cause of mortality. It is difficult to induce immunological memory against malarial parasites, Plasmodium. The immunity to clinical malaria disease is acquired with multiple infection and treatment cycles, along with substantial reduction in parasite burden. However, the mechanism of the acquired immunity remains largely unclear. Conventional dendritic cells (cDCs) play a pivotal role in orchestration of immune responses. The purpose of this study is to analyze the characterization of cDCs after the infection and cure treatment cycles.

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