The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10168 malaria professionals are enjoying the free benefits of MalariaWorld today

causal pathways

Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies

September 9, 2019 - 16:47 -- Open Access
Author(s): 
Stije J. Leopold, James A. Watson, Atthanee Jeeyapant, Julie A. Simpson, Nguyen H. Phu, Tran T. Hien, Nicholas P. J. Day, Arjen M. Dondorp, Nicholas J. White
Reference: 
PLoS Med 16(8): e1002858

Severe falciparum malaria is a medical emergency characterised by potentially lethal vital organ dysfunction. Patient fatality rates even with parenteral artesunate treatment remain high. Despite considerable research into adjuvant therapies targeting organ and tissue dysfunction, none have shown efficacy apart from renal replacement therapy. Understanding the causal contributions of clinical and laboratory abnormalities to mortality is essential for the design and evaluation of novel therapeutic interventions.

Subscribe to RSS - causal pathways