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II rosettes

Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis

February 22, 2020 - 17:21 -- Open Access
Author(s): 
Lee WC, Russell B, Sobota RM, Ghaffar K, Howland SW, Wong ZX, Maier AG, Dorin-Semblat D, Biswas S, Gamain B, Lau YL, Malleret B, Chu C, Nosten F, Renia L
Reference: 
Elife. 2020 Feb 18;9. pii: e51546

In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated with malaria pathogenesis. Here, we have identified a new type of rosetting. Using a step-by-step approach, we identified IGFBP7, a protein secreted by monocytes in response to parasite stimulation, as a rosette-stimulator for Plasmodium falciparum- and P. vivax-IRBC. IGFBP7-mediated rosette-stimulation was rapid yet reversible.

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