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chloroquine sensitivity

Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda

February 22, 2020 - 16:49 -- Open Access
Author(s): 
Betty Balikagala, Miki Sakurai-Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert T. Katuro, Edward H. Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul S. Obwoya, Denis A. Anywar, Mary A. Auma, Nirianne M. Q. Palacpac, Takafumi Tsuboi, Emmanuel I. Odongo-Aginya, Eisaku Kimura, Martin Ogwang, Toshihiro Horii & Toshihiro Mita
Reference: 
Malaria Journal 2020 19:76, 18 February 2020

Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiological studies have demonstrated that the discontinuance led to re‑emergence of chloroquine‑susceptible P. falciparum, suggesting a possible role in future malaria control. However, most studies were cross‑sectional, with few studies looking at the persistence of chloroquine recovery in long term. This study fills the gap by providing, for a period of at least 6 years, proof of persistent re‑emergence/stable recovery of susceptible parasite populations using both molecular and phenotypic methods.

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