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var gene regulation

PfSWIB, a potential chromatin regulator for var gene regulation and parasite development in Plasmodium falciparum

February 14, 2020 - 17:03 -- Open Access
Wang WF, Zhang YL
Parasites & Vectors volume 13, 48 (2020)

Various transcription factors are involved in the process of mutually exclusive expression and clonal variation of the Plasmodium multigene (var) family. Recent studies revealed that a P. falciparum SWI/SNF-related matrix-associated actin-dependent regulator of chromatin (PfSWIB) might trigger stage-specific programmed cell death (PCD), and was not only crucial for the survival and development of parasite, but also had profound effects on the parasite by interacting with other unknown proteins. However, it remains unclear whether PfSIWB is involved in transcriptional regulation of this virulence gene and its functional properties.

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