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cysteine protease

A Plasmodium cysteine protease required for efficient transition from the liver infection stage

September 23, 2020 - 08:55 -- Open Access
Putrianti ED, Schmidt-Christensen A, Heussler V, Matuschewski K, Ingmundson A
PLoS Pathog. 2020 Sep 21;16(9):e1008891

The transitions between developmental stages are critical points in the Plasmodium life cycle. The development of Plasmodium in the livers of their mammalian hosts bridges malaria transmission and the onset of clinical symptoms elicited by red blood cell infection. The egress of Plasmodium parasites from the liver must be a carefully orchestrated process to ensure a successful switch to the blood stage of infection.

NOT Open Access | Discovery of a natural fluorescent probe targeting the Plasmodium falciparum cysteine protease falcipain-2

February 16, 2020 - 09:15 -- NOT Open Access
Zhu L, Shan L, Zhu J, Li L, Li S, Wang L, Wang J, Zhang S, Zhou H, Zhang W, Li H
Sci China Life Sci. 2020 Feb 9

The Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is an attractive antimalarial target. Here, we discovered that the natural compound NP1024 is a nonpeptidic inhibitor of FP-2 with an IC50 value of 0.44 μmol L−1.

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