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fluorescent probe

NOT Open Access | Discovery of a natural fluorescent probe targeting the Plasmodium falciparum cysteine protease falcipain-2

February 16, 2020 - 09:15 -- NOT Open Access
Zhu L, Shan L, Zhu J, Li L, Li S, Wang L, Wang J, Zhang S, Zhou H, Zhang W, Li H
Sci China Life Sci. 2020 Feb 9

The Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is an attractive antimalarial target. Here, we discovered that the natural compound NP1024 is a nonpeptidic inhibitor of FP-2 with an IC50 value of 0.44 μmol L−1.

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