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constrained peptides

NOT Open Access | Targeting Plasmodium with constrained peptides and peptidomimetics

February 17, 2020 - 15:03 -- NOT Open Access
Helton LG, Kennedy EJ
IUBMB Life. 2020 Feb 10

Malaria remains a worldwide health concern with an estimated quarter of a billion people infected and nearly half a million deaths annually. Malaria is caused by a parasite infection from Plasmodium strains which are transmitted from mosquitoes into the human host. Although several small molecule inhibitors have been found to target the early stages of transmission and prevent parasite proliferation, multiple drug resistant parasite strains have emerged and drug resistance remains a major hurdle.

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