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host rhythms

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

June 3, 2020 - 15:54 -- Open Access
Author(s): 
Subudhi AK, O'Donnell AJ, Pain A, et al.
Reference: 
Nat Commun. 2020 Jun 2; 11(1):2763

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown.

NOT Open Access | Periodic Parasites and Daily Host Rhythms

February 17, 2020 - 14:45 -- NOT Open Access
Author(s): 
Prior KF, Rijo-Ferreira F, Assis PA, Hirako IC, Weaver DR, Gazzinelli RT, Reece SE
Reference: 
Cell Host Microbe. 2020 Feb 12;27(2):176-187

Biological rhythms appear to be an elegant solution to the challenge of coordinating activities with the consequences of the Earth’s daily and seasonal rotation. The genes and molecular mechanisms underpinning circadian clocks in multicellular organisms are well understood. In contrast, the regulatory mechanisms and fitness consequences of biological rhythms exhibited by parasites remain mysterious. Here, we explore how periodicity in parasite traits is generated and why daily rhythms matter for parasite fitness.

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