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NOT Open Access | Inhibition of PfMYST HAT activity blocks Plasmodium falciparum growth and survival

October 14, 2020 - 12:29 -- NOT Open Access
Sen U, Nayak A, Khurana J, Sharma D, Gupta A
Antimicrob Agents Chemother. 2020 Oct 12:AAC.00953-20

One of the major barrier in the prevention & control of malaria programs worldwide is the growing emergence of multidrug-resistance in Plasmodium parasite and demands continued efforts to discover & develop effective drug molecules targeting novel proteins essential for parasite survival. In recent years, epigenetic regulators have evolved as an attractive drug target option owing to their crucial role in survival and development of Plasmodium at different stages of its life cycle.

The nuclear 18S ribosomal DNAs of avian haemosporidian parasites

September 10, 2019 - 15:36 -- Open Access
Josef Harl, Tanja Himmel, Gediminas Valkiūnas and Herbert Weissenböck
Malaria Journal 2019 18:305, 3 September 2019

Plasmodium species feature only four to eight nuclear ribosomal units on different chromosomes, which are assumed to evolve independently according to a birth-and-death model, in which new variants originate by duplication and others are deleted throughout time. Moreover, distinct ribosomal units were shown to be expressed during different developmental stages in the vertebrate and mosquito hosts. Here, the 18S rDNA sequences of 32 species of avian haemosporidian parasites are reported and compared to those of simian and rodent Plasmodium species.

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