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hemozoin formation inhibitor

Preclinical Antimalarial Combination Studies: The Case of M5717, a P. falciparum Elongation Factor 2 Inhibitor and Pyronaridine, a Hemozoin Formation Inhibitor

February 17, 2020 - 14:33 -- Open Access
Rottmann M, Jonat B, Spangenberg T, et al.
Antimicrob Agents Chemother. 2020 Feb 10, pii: AAC.02181-19.

Antimalarial drug resistance in the Plasmodium falciparum parasite poses a constant challenge for drug development. To mitigate this risk, new antimalarial medicines should be developed as fixed-dose combinations. Assessing the pharmacodynamic interactions of potential antimalarial drug combination partners during early phases of development is essential in developing the targeted parasitological and clinical profile of the final drug product.

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