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NOT Open Access | Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

October 28, 2020 - 09:55 -- NOT Open Access
Kleks G, Holland DC, Kennedy EK, Avery VM, Carroll AR
J Nat Prod. 2020 Oct 26

An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi resulted in the isolation of six new brominated alkaloids, convolutamines K and L (1 and 2), volutamides F-H (3-5), and 2,5-dibromo-1-methyl-1H-indole-3-carbaldehyde (6).

Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia

August 24, 2020 - 15:20 -- Open Access
Watts RE, Odedra A, McCarthy JS, et al.
PLoS Med. 2020 Aug 21;17(8):e1003203

Artemisinin resistance is threatening malaria control. We aimed to develop and test a human model of artemisinin-resistant (ART-R) Plasmodium falciparum to evaluate the efficacy of drugs against ART-R malaria.

Molecular detection of antimalarial drug resistance in Plasmodium vivax from returned travellers to NSW, Australia during 2008-2018

February 16, 2020 - 09:23 -- Open Access
Noisang C, Meyer W, Sawangjaroen N, Ellis J, Lee R
Pathogens. 2020 Feb 5;9(2). pii: E101

To monitor drug resistance in Plasmodium vivax, a multidrug resistance 1 (Pvmdr1) gene and a putative transporter protein (Pvcrt-o) gene were used as molecular markers for chloroquine resistance. The biomarkers, the dihydrofolate reductase (Pvdhfr) gene and the dihydropteroate synthetase (Pvdhps) gene, were also used for the detection of resistance to sulphadoxine-pyrimethamine (SP); this drug is often accidentally used to treat P. vivax infections. Clinical blood samples (n = 120) were collected from patients who had been to one of eight malaria-endemic countries and diagnosed with P. vivax infection.

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