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malaria-resistance

Not Open Access | "Dual-gene" malaria-resistance: Therapeutically-rational exchange (T-REX) of group-O sickle trait and group-O C-trait red blood cells can be evaluated in Benin and Nigeria

February 13, 2020 - 15:00 -- NOT Open Access
Author(s): 
Jajosky RP, Jajosky AN, Jajosky PG
Reference: 
Transfus Apher Sci. 2020 Jan 27:102733

Using indicators of disease severity, clinicians can predict which Plasmodium falciparum (Pf) malaria patients being treated with artesunate or quinine are likely to die despite these drugs. Effective "rescue adjuncts" are needed when drugs alone are inadequate. "Therapeutically-rational exchange" (T-REX) of special malaria-resistant red blood cells (RBCs) has been proposed to optimize adjunctive exchange transfusion.

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