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transmission areas

Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas

February 11, 2020 - 15:51 -- Open Access
Author(s): 
Yaw Aniweh, Jonathan Suurbaar, Gordon A. Awandare, et al.
Reference: 
Sci Rep. 2020; 10:1498.

Despite significant progress in controlling malaria, the disease remains a global health burden. The intricate interactions the parasite Plasmodium falciparum has with its host allows it to grow and multiply in human erythrocytes. The mechanism by which P. falciparum merozoites invade human erythrocytes is complex, involving merozoite proteins as well as erythrocyte surface proteins. Members of the P. falciparum reticulocyte binding-like protein homolog (PfRh) family of proteins play a pivotal role in merozoite invasion and hence are important targets of immune responses.

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