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NOT Open Access | MHC Class II (DRB) Promoter Polymorphism and Its Role in Parasite Control among Malaria Patients

January 27, 2020 - 13:21 -- NOT Open Access
Sar P, Agarwal A, Vadodariya DH, Kariya H, Khuman J, Dalai S
J Immunol January 15, 2020, ji1900558

MHC class II (MHCII) molecules are cell surface glycoproteins that play an important role to develop adaptive immune responses. MHCII-disease association is not restricted to structural variation alone but also may extend to genetic variations, which may modulate gene expression. The observed variations in class II gene expression make it possible that the association of MHCII polymorphism with diseases may relate to the level of gene expression in addition to the restriction of response to Ag.

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