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Southeast Asia

NOT Open Access | Treating Severe Malaria

October 1, 2020 - 15:44 -- NOT Open Access
Author(s): 
Berman JD
Reference: 
Clin Infect Dis. 2020 Sep 30:ciaa887

In “Concomitant bacteremia in adults with severe falciparum malaria” in this issue of Clinical Infectious Diseases, 9 of 845 Southeast Asian adults with severe malaria (1%) had bacteremia upon admission, but 4 of those 9 patients (44%) died compared with 108 of 836 (13%) nonbacteremic patients.

Syk Inhibitors: New Computational Insights into Their Intraerythrocytic Action in Plasmodium falciparum Malaria

September 29, 2020 - 13:17 -- Open Access
Author(s): 
Marchetti G, Dessì A, Dallocchio R, Tsamesidis I, Pau MC, Turrini FM, Pantaleo A
Reference: 
Mol Sci. 2020 Sep 23;21(19):E7009

Resistance to antimalarial drugs has spread rapidly over the past few decades. The WHO recommends artemisinin-based combination therapies for the treatment of uncomplicated malaria, but unfortunately these approaches are losing their efficacy in large areas of Southeast Asia. In 2016, artemisinin resistance was confirmed in 5 countries of the Greater Mekong subregion. We focused our study on Syk inhibitors as antimalarial drugs.

NOT Open Access | Serratia marcescens secretes proteases and chitinases with larvicidal activity against Anopheles dirus

September 1, 2020 - 13:46 -- NOT Open Access
Author(s): 
Jupatanakul N, Pengon J, Selisana SMG, Choksawangkarn W, Jaito N, Saeung A, Bunyong R, Posayapisit N, Thammatinna K, Kalpongnukul N, Aupalee K, Pisitkun T, Kamchonwongpaisan S
Reference: 
Acta Trop. 2020 Aug 28:105686

Vector control, the most efficient tool to reduce mosquito-borne disease transmission, has been compromised by the rise of insecticide resistance. Recent studies suggest the potential of mosquito-associated microbiota as a source for new biocontrol agents or new insecticidal chemotypes. In this study, we identified a strain of Serratia marcescens that has larvicidal activity against Anopheles dirus, an important malaria vector in Southeast Asia.

Population genomics identifies a distinct Plasmodium vivax population on the China-Myanmar border of Southeast Asia

August 5, 2020 - 14:17 -- Open Access
Author(s): 
Brashear AM, Fan Q, Hu Y, Li Y, Zhao Y, Wang Z, Cao Y, Miao J, Barry A, Cui L.
Reference: 
PLoS Negl Trop Dis 14(8): e0008506

Plasmodium vivax has become the predominant malaria parasite and a major challenge for malaria elimination in the Greater Mekong Subregion (GMS). Yet, our knowledge about the evolution of P. vivax populations in the GMS is fragmental. We performed whole genome sequencing on 23 P. vivax samples from the China-Myanmar border (CMB) and used 21 high-coverage samples to compare to over 200 samples from the rest of the GMS.

NOT Open Access | Efficacy and Safety of a Naphthoquine-Azithromycin Co-Formulation for Malaria Prophylaxis in Southeast Asia: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial

July 21, 2020 - 15:13 -- NOT Open Access
Author(s): 
Yang H, Wang J, Cui L, et al.
Reference: 
Clin Infect Dis. 2020 Jul 20:ciaa1018

A prophylactic antimalarial drug that is both effective for protection and improves compliance is in high demand.

NOT Open Access | Is the Epidemiology of Plasmodium knowlesi Changing, and What Does This Mean for Malaria Control in Southeast Asia?

January 20, 2020 - 16:31 -- NOT Open Access
Author(s): 
Karunajeewa H, Berman J
Reference: 
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 368–369

It has long been clear that the “monkey-malaria” species, Plasmodium knowlesi, is capable of infecting humans. Its name comes from Robert Knowles, the British parasitologist who first demonstrated experimental monkey–human transmission and pioneered its use as “malaria therapy” for syphilis and leprosy from as early as 1932 [1].

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