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blood stages

NOT Open Access | Whole parasite vaccines for the asexual blood stages of Plasmodium

January 20, 2020 - 15:16 -- NOT Open Access
Author(s): 
Good MF, Stanisic DI
Reference: 
Immunological Reviews, Volume293, Issue1 January 2020, Pages 270-282

After many decades of research, an effective vaccine for malaria is still not available. Most research efforts have focused on identifying a key target antigen and then using powerful adjuvants to generate specific antibodies that can block parasites from entering host cells (hepatocytes, red blood cells). However, the inability to generate sufficiently potent antibody responses has led to significant disappointment with current vaccine programs.

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