All malaria-endemic countries in Africa are on a sliding scale towards a malaria-free future. Bold and ambitious goals around malaria elimination were adopted by the United Nations General Assembly in September 2015 through target 3.3 of the Sustainable Development Goals; by Africa’s leaders through the Africa Agenda 2063; and by the World Health Assembly in May 2015 through the Global Technical Strategy for Malaria 2016–2030, known as the GTS. The GTS has four 2030 goals and targets: reduce malaria mortality rates globally by at least 90% compared with 2015; reduce malaria case incidence globally by at least 90% compared with 2015; eliminate malaria from at least 35 countries in which malaria was transmitted in 2015; and prevent re-establishment of malaria in all countries that are malaria-free. The post-2015 period therefore presents a scenario of bold reforms intended to actualize a malaria-free future. In order to align the GTS to the African context, the Framework for implementing the Global Technical Strategy for Malaria 2016–2030 in the African Region was developed.