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Costing malaria interventions from pilots to elimination programmes

September 15, 2020 - 10:34 -- Open Access
Katya Galactionova, Mar Velarde, Kafula Silumbe, John Miller, Anthony McDonnell, Ricardo Aguas, Thomas A. Smith and Melissa A. Penny
Malaria Journal 2020 19:332, 14 September 2020

Malaria programmes in countries with low transmission levels require evidence to optimize deployment of current and new tools to reach elimination with limited resources. Recent pilots of elimination strategies in Ethiopia, Senegal, and Zambia produced evidence of their epidemiological impacts and costs. There is a need to generalize these findings to different epidemiological and health systems contexts.

Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal

August 4, 2020 - 15:59 -- Open Access
Rachel F. Daniels, Stephen F. Schaffner, Yakou Dieye, et al.
Malaria Journal 2020 19:276, 3 August 2020

Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history.

Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

July 15, 2020 - 15:17 -- Open Access
Ruben O. Conner, Yakou Dieye, Caterina Guinovart, et al.
Malaria Journal 2020 19:252, 14 July 2020

Population-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and accelerate towards elimination. Questions remain about their effectiveness and evidence from different transmission settings is needed.

Efficacy and safety of artemisinin-based combination therapy and the implications of Pfkelch13 and Pfcoronin molecular markers in treatment failure in Senegal

June 2, 2020 - 14:08 -- Open Access
Diallo MA, Yade MS, Ndiaye D, et al.
Sci Rep. 2020 Jun 1; 10(1):8907

In 2006, Senegal adopted artemisinin-based combination therapy (ACT) as first-line treatment in the management of uncomplicated malaria. This study aimed to update the status of antimalarial efficacy more than ten years after their first introduction. This was a randomized, three-arm, open-label study to evaluate the efficacy and safety of artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DP) in Senegal.

A twenty-eight-year laboratory-based retrospective trend analysis of malaria in Dakar, Senegal

May 19, 2020 - 14:45 -- Open Access
Diallo MA, Badiane AS, Diongue K, Sakandé L, Ndiaye M, Seck MC, Ndiaye D.
PLoS ONE 15(5): e0231587

Health facility-based records offer a rich source of information to understand trends and changes in malaria cases over time. This study is aimed at determining the changes in malaria occurrence over the last 28 years, from 1989 to 2016 in Dakar, Senegal.

Proactive community case management in Senegal 2014–2016: a case study in maximizing the impact of community case management of malaria

April 27, 2020 - 13:25 -- Open Access
Seynabou Gaye, Janelle Kibler, Julie Thwing, et al.
Malaria Journal 2020 19:166, 25 April 2020

The Senegal National Malaria Control Programme (NMCP) introduced home-based malaria management for all ages, with diagnosis by rapid diagnostic test (RDT) and treatment with artemisinin-based combination therapy (ACT) in 2008, expanding to over 2000 villages nationwide by 2014. With prise en charge à domicile (PECADOM), community health workers (CHWs) were available for community members to seek care, but did not actively visit households to find cases.

Amplicon deep sequencing of kelch13 in Plasmodium falciparum isolates from Senegal

March 31, 2020 - 16:01 -- Open Access
Amy Gaye, Mouhamad Sy, Daouda Ndiaye, et al.
Malaria Journal 2020 19:134, 30 March 2020

In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) with artemether–lumefantrine as the first-line treatment for uncomplicated Plasmodium falciparum malaria. To date, multiple mutations associated with artemisinin delayed parasite clearance have been described in Southeast Asia in the Pfk13 gene, such as Y493H, R539T, I543T and C580Y. Even though ACT remains clinically and parasitologically efficacious in Senegal, the spread of resistance is possible as shown by the earlier emergence of resistance to chloroquine in Southeast Asia that subsequently spread to Africa. Therefore, surveillance of artemisinin resistance in malaria endemic regions is crucial and requires the implementation of sensitive tools, such as next-generation sequencing (NGS) which can detect novel mutations at low frequency.

Molecular detection and quantification of Plasmodium falciparum gametocytes carriage in used RDTs in malaria elimination settings in northern Senegal

March 31, 2020 - 15:17 -- Open Access
Kiswendsida Thierry Guiguemde, Yakou Dieye, Babacar Faye, et al.
Malaria Journal 2020 19:123, 30 March 2020

Malaria surveillance requires powerful tools and strategies to achieve malaria elimination. Rapid diagnostic tests for malaria (RDTs) are easily deployed on a large scale and are helpful sources of parasite DNA. The application of sensitive molecular techniques to these RDTs is a modern tool for improving malaria case detection and drug resistance surveillance. Several studies have made it possible to extract the DNA of Plasmodium falciparum from RDTs. The knowledge of gametocyte carriage in the population is important to better assess the level of parasite transmission in elimination settings. The aim of this study was to detect P. falciparum gametocytes from used RDTs by quantitative PCR for molecular monitoring of malaria transmission.

Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure

January 15, 2020 - 14:36 -- Open Access
Mame Cheikh Seck, Julie Thwing, Aida Sadikh Badiane, Eric Rogier, Fatou Ba Fall, Pape Ibrahima Ndiaye, Khadim Diongue, Moustapha Mbow, Mouhamadou Ndiaye, Mamadou Alpha Diallo, Jules François Gomis, Aminata Mbaye, Tolla Ndiaye, Aminata Gaye, Mohamad Sy, Awa Bineta Déme, Yaye Die Ndiaye & Daouda Ndiaye
Malaria Journal 2020 19:15, 13 January 2020

Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150–450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys.

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