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Molecular epidemiology of Plasmodium falciparum by multiplexed amplicon deep sequencing in Senegal

November 11, 2020 - 14:30 -- Open Access
Tolla Ndiaye, Mouhamad Sy, Daouda Ndiaye, et al.
Malaria Journal 2020 19:403, 10 November 2020

Molecular epidemiology can provide important information regarding the genetic diversity and transmission of Plasmodium falciparum, which can assist in designing and monitoring elimination efforts. However, malaria molecular epidemiology including understanding the genetic diversity of the parasite and performing molecular surveillance of transmission has been poorly documented in Senegal. Next Generation Sequencing (NGS) offers a practical, fast and high-throughput approach to understand malaria population genetics. This study aims to unravel the population structure of P. falciparum and to estimate the allelic diversity, multiplicity of infection (MOI), and evolutionary patterns of the malaria parasite using the NGS platform.

NOT Open Access | The Impact of Renewing Long-Lasting Insecticide-Treated Nets in the Event of Malaria Resurgence: Lessons from 10 Years of Net Use in Dielmo, Senegal

October 21, 2020 - 09:29 -- NOT Open Access
Wotodjo AN, Doucoure S, Diagne N, Sarr FD, Parola P, Gaudart J, Sokhna C
Am J Trop Med Hyg. 2020 Oct 19

The occurrence of malaria resurgences could threaten progress toward elimination of the disease. This study investigated the impact of repeated renewal of long-lasting insecticide-treated net (LLIN) universal coverage on malaria resurgence over a period of 10 years of net implementation in Dielmo (Senegal). A longitudinal study was carried out in Dielmo between August 2007 and July 2018. In July 2008, LLINs were offered to all villagers through universal campaign distribution which was renewed in July 2011, August 2014, and May 2016. Malaria cases were treated with artemisinin-based combination therapy.

NOT Open Access | Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal

October 15, 2020 - 08:36 -- NOT Open Access
Delandre O, Daffe SM, Pradines B, et al.
Int J Antimicrob Agents. 2020 Oct 9:106190

Due to resistance to chloroquine and sulfadoxine-pyrimethamine, treatment for uncomplicated Plasmodium falciparum malaria switched to artemisinin-based combination therapy (ACT) in 2006 in Senegal. Several mutations in the gene coding the kelch13 helix (pfk13-propeller) were identified to be associated with in vitro and in vivo artemisinin resistance in Southeast Asia.

Costing malaria interventions from pilots to elimination programmes

September 15, 2020 - 10:34 -- Open Access
Katya Galactionova, Mar Velarde, Kafula Silumbe, John Miller, Anthony McDonnell, Ricardo Aguas, Thomas A. Smith and Melissa A. Penny
Malaria Journal 2020 19:332, 14 September 2020

Malaria programmes in countries with low transmission levels require evidence to optimize deployment of current and new tools to reach elimination with limited resources. Recent pilots of elimination strategies in Ethiopia, Senegal, and Zambia produced evidence of their epidemiological impacts and costs. There is a need to generalize these findings to different epidemiological and health systems contexts.

Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal

August 4, 2020 - 15:59 -- Open Access
Rachel F. Daniels, Stephen F. Schaffner, Yakou Dieye, et al.
Malaria Journal 2020 19:276, 3 August 2020

Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history.

Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

July 15, 2020 - 15:17 -- Open Access
Ruben O. Conner, Yakou Dieye, Caterina Guinovart, et al.
Malaria Journal 2020 19:252, 14 July 2020

Population-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and accelerate towards elimination. Questions remain about their effectiveness and evidence from different transmission settings is needed.

Efficacy and safety of artemisinin-based combination therapy and the implications of Pfkelch13 and Pfcoronin molecular markers in treatment failure in Senegal

June 2, 2020 - 14:08 -- Open Access
Diallo MA, Yade MS, Ndiaye D, et al.
Sci Rep. 2020 Jun 1; 10(1):8907

In 2006, Senegal adopted artemisinin-based combination therapy (ACT) as first-line treatment in the management of uncomplicated malaria. This study aimed to update the status of antimalarial efficacy more than ten years after their first introduction. This was a randomized, three-arm, open-label study to evaluate the efficacy and safety of artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DP) in Senegal.

A twenty-eight-year laboratory-based retrospective trend analysis of malaria in Dakar, Senegal

May 19, 2020 - 14:45 -- Open Access
Diallo MA, Badiane AS, Diongue K, Sakandé L, Ndiaye M, Seck MC, Ndiaye D.
PLoS ONE 15(5): e0231587

Health facility-based records offer a rich source of information to understand trends and changes in malaria cases over time. This study is aimed at determining the changes in malaria occurrence over the last 28 years, from 1989 to 2016 in Dakar, Senegal.

Proactive community case management in Senegal 2014–2016: a case study in maximizing the impact of community case management of malaria

April 27, 2020 - 13:25 -- Open Access
Seynabou Gaye, Janelle Kibler, Julie Thwing, et al.
Malaria Journal 2020 19:166, 25 April 2020

The Senegal National Malaria Control Programme (NMCP) introduced home-based malaria management for all ages, with diagnosis by rapid diagnostic test (RDT) and treatment with artemisinin-based combination therapy (ACT) in 2008, expanding to over 2000 villages nationwide by 2014. With prise en charge à domicile (PECADOM), community health workers (CHWs) were available for community members to seek care, but did not actively visit households to find cases.

Amplicon deep sequencing of kelch13 in Plasmodium falciparum isolates from Senegal

March 31, 2020 - 16:01 -- Open Access
Amy Gaye, Mouhamad Sy, Daouda Ndiaye, et al.
Malaria Journal 2020 19:134, 30 March 2020

In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) with artemether–lumefantrine as the first-line treatment for uncomplicated Plasmodium falciparum malaria. To date, multiple mutations associated with artemisinin delayed parasite clearance have been described in Southeast Asia in the Pfk13 gene, such as Y493H, R539T, I543T and C580Y. Even though ACT remains clinically and parasitologically efficacious in Senegal, the spread of resistance is possible as shown by the earlier emergence of resistance to chloroquine in Southeast Asia that subsequently spread to Africa. Therefore, surveillance of artemisinin resistance in malaria endemic regions is crucial and requires the implementation of sensitive tools, such as next-generation sequencing (NGS) which can detect novel mutations at low frequency.


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