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Genomic investigation of atypical malaria cases in Kanel, northern Senegal

February 23, 2021 - 14:10 -- Open Access
Mouhamad Sy, Aida Sadikh Badiane, Doudou Sène, et al.
Malaria Journal 2021 20:103, 19 February 2021

The diagnosis of malaria cases in regions where the malaria burden has decreased significantly and prevalence is very low is more challenging, in part because of reduced clinical presumption of malaria. The appearance of a cluster of malaria cases with atypical symptoms in Mbounguiel, a village in northern Senegal where malaria transmission is low, in September 2018 exemplifies this scenario. The collaboration between the National Malaria Control Programme (NMCP) at the Senegal Ministry of Health and the Laboratory of Parasitology and Mycology at Cheikh Anta Diop University worked together to evaluate this cluster of malaria cases using molecular and serological tools.

Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations

January 13, 2021 - 10:18 -- Open Access
Mary A. Oboh, Tolla Ndiaye, Daouda Ndiaye, et al.
Malaria Journal 2021 20:38, 13 January 2021

Characterizing the genetic diversity of malaria parasite populations in different endemic settings (from low to high) could be helpful in determining the effectiveness of malaria interventions. This study compared Plasmodium falciparum parasite population diversity from two sites with low (pre-elimination) and high transmission in Senegal and Nigeria, respectively.

Targeting Malaria Hotspots to Reduce Transmission Incidence in Senegal

January 1, 2021 - 15:54 -- Open Access
Sallah K, Giorgi R, Ba EH, Piarroux M, Piarroux R, Cisse B, Gaudart J
Int J Environ Res Public Health. 2020 Dec 24;18(1):E76

In central Senegal, malaria incidence declined in response to scaling-up of control measures from 2000 to 2010 and has since remained stable, making elimination unlikely in the short term. Additional control measures are needed to reduce transmission. We simulated chemoprophylaxis interventions targeting malaria hotspots using a metapopulation mathematical model, based on a differential-equation framework and incorporating human mobility. The model was fitted to weekly malaria incidence from 45 villages.

Mapping the breeding sites of Anopheles gambiae s. l. in areas of residual malaria transmission in central western Senegal

December 15, 2020 - 14:43 -- Open Access
Ndiaye A, Niang EHA, Diène AN, Nourdine MA, Sarr PC, Konaté L, Faye O, Gaye O, Sy O
PLoS One. 2020 Dec 11;15(12):e0236607

Despite the deployment of several effective control interventions in central-western Senegal, residual malaria transmission is still occurring in some hotspots. To better tailor targeted control actions, it is critical to unravel the underlying environmental and geographical factors that cause the persistence infection in hotspot villages. "Hotspots villages" were defined in our study as those reporting more than six indigenous malaria cases during the previous year. A total of ten villages, including seven hotspots and three non-hotspots, were surveyed.

Molecular epidemiology of Plasmodium falciparum by multiplexed amplicon deep sequencing in Senegal

November 11, 2020 - 14:30 -- Open Access
Tolla Ndiaye, Mouhamad Sy, Daouda Ndiaye, et al.
Malaria Journal 2020 19:403, 10 November 2020

Molecular epidemiology can provide important information regarding the genetic diversity and transmission of Plasmodium falciparum, which can assist in designing and monitoring elimination efforts. However, malaria molecular epidemiology including understanding the genetic diversity of the parasite and performing molecular surveillance of transmission has been poorly documented in Senegal. Next Generation Sequencing (NGS) offers a practical, fast and high-throughput approach to understand malaria population genetics. This study aims to unravel the population structure of P. falciparum and to estimate the allelic diversity, multiplicity of infection (MOI), and evolutionary patterns of the malaria parasite using the NGS platform.

NOT Open Access | The Impact of Renewing Long-Lasting Insecticide-Treated Nets in the Event of Malaria Resurgence: Lessons from 10 Years of Net Use in Dielmo, Senegal

October 21, 2020 - 09:29 -- NOT Open Access
Wotodjo AN, Doucoure S, Diagne N, Sarr FD, Parola P, Gaudart J, Sokhna C
Am J Trop Med Hyg. 2020 Oct 19

The occurrence of malaria resurgences could threaten progress toward elimination of the disease. This study investigated the impact of repeated renewal of long-lasting insecticide-treated net (LLIN) universal coverage on malaria resurgence over a period of 10 years of net implementation in Dielmo (Senegal). A longitudinal study was carried out in Dielmo between August 2007 and July 2018. In July 2008, LLINs were offered to all villagers through universal campaign distribution which was renewed in July 2011, August 2014, and May 2016. Malaria cases were treated with artemisinin-based combination therapy.

NOT Open Access | Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal

October 15, 2020 - 08:36 -- NOT Open Access
Delandre O, Daffe SM, Pradines B, et al.
Int J Antimicrob Agents. 2020 Oct 9:106190

Due to resistance to chloroquine and sulfadoxine-pyrimethamine, treatment for uncomplicated Plasmodium falciparum malaria switched to artemisinin-based combination therapy (ACT) in 2006 in Senegal. Several mutations in the gene coding the kelch13 helix (pfk13-propeller) were identified to be associated with in vitro and in vivo artemisinin resistance in Southeast Asia.

Costing malaria interventions from pilots to elimination programmes

September 15, 2020 - 10:34 -- Open Access
Katya Galactionova, Mar Velarde, Kafula Silumbe, John Miller, Anthony McDonnell, Ricardo Aguas, Thomas A. Smith and Melissa A. Penny
Malaria Journal 2020 19:332, 14 September 2020

Malaria programmes in countries with low transmission levels require evidence to optimize deployment of current and new tools to reach elimination with limited resources. Recent pilots of elimination strategies in Ethiopia, Senegal, and Zambia produced evidence of their epidemiological impacts and costs. There is a need to generalize these findings to different epidemiological and health systems contexts.

Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal

August 4, 2020 - 15:59 -- Open Access
Rachel F. Daniels, Stephen F. Schaffner, Yakou Dieye, et al.
Malaria Journal 2020 19:276, 3 August 2020

Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history.

Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact

July 15, 2020 - 15:17 -- Open Access
Ruben O. Conner, Yakou Dieye, Caterina Guinovart, et al.
Malaria Journal 2020 19:252, 14 July 2020

Population-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and accelerate towards elimination. Questions remain about their effectiveness and evidence from different transmission settings is needed.


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