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sensory appendage protein

NOT Open Access | A sensory appendage protein protects malaria vectors from pyrethroids

January 15, 2020 - 09:05 -- NOT Open Access
Author(s): 
Ingham VA, Anthousi A, Douris V, Harding NJ, Lycett G, Morris M, Vontas J, Ranson H
Reference: 
Nature volume 577, pages376–380(2020)

Pyrethroid-impregnated bed nets have driven considerable reductions in malaria-associated morbidity and mortality in Africa since the beginning of the century1. The intense selection pressure exerted by bed nets has precipitated widespread and escalating resistance to pyrethroids in African Anopheles populations, threatening to reverse the gains that been made by malaria control2. Here we show that expression of a sensory appendage protein (SAP2), which is enriched in the legs, confers pyrethroid resistance to Anopheles gambiae.

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