The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10326 malaria professionals are enjoying the free benefits of MalariaWorld today

screening

Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening

January 15, 2020 - 09:27 -- Open Access
Author(s): 
Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E
Reference: 
PLoS ONE 14(12): e0226270

Dipeptidyl aminopeptidases (DPAPs) are cysteine proteases that cleave dipeptides from the N-terminus of protein substrates and have been shown to play important roles in many pathologies including parasitic diseases such as malaria, toxoplasmosis and Chagas’s disease. Inhibitors of the mammalian homologue cathepsin C have been used in clinical trials as potential drugs to treat chronic inflammatory disorders, thus proving that these enzymes are druggable.

Subscribe to RSS - screening