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sporozoites

Determinants of Malaria Protective Immunity in Mice Immunized with Live Sporozoites during Trimethoprim-Sulfamethoxazole Prophylaxis

December 23, 2020 - 09:04 -- Open Access
Author(s): 
Hobbs CV, Sahu T, Neal J, Conteh S, Voza T, Borkowsky W, Langhorne J, Duffy PE
Reference: 
Am J Trop Med Hyg. 2020 Dec 21

HIV and malaria geographically overlap. Trimethoprim-sulfamethoxazole (TMP-SMX) is a drug widely used in HIV-exposed uninfected and infected children in malaria-endemic areas, and is known to have antimalarial effects. Further study in terms of antimalarial impact and effect on development of malaria-specific immunity is therefore essential. Using rodent malaria models, we previously showed that repeated Plasmodium exposure during TMP-SMX administration, or chemoprophylaxis vaccination (CVac), induces CD8 T-cell-dependent preerythrocytic immunity.

Modelling the roles of antibody titre and avidity in protection from Plasmodium falciparum malaria infection following RTS,S/AS01 vaccination

November 3, 2020 - 14:42 -- Open Access
Author(s): 
Thompson HA, Hogan AB, Walker PGT, White MT, Cunnington AJ, Ockenhouse CF, Ghani AC
Reference: 
Vaccine. 2020 Nov 3;38(47):7498-7507

Anti-circumsporozoite antibody titres have been established as an essential indicator for evaluating the immunogenicity and protective capacity of the RTS,S/AS01 malaria vaccine.

Overlapping and distinct roles of CDPK family members in the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium berghei

September 1, 2020 - 13:43 -- Open Access
Author(s): 
Govindasamy K, Bhanot P
Reference: 
PLoS Pathog. 2020 Aug 31;16(8):e1008131

Invasion of hepatocytes by Plasmodium sporozoites initiates the pre-erythrocytic step of a malaria infection. Subsequent development of the parasite within hepatocytes and exit from them is essential for starting the disease-causing erythrocytic cycle. Identification of signaling pathways that operate in pre-erythrocytic stages provides insight into a critical step of infection and potential targets for chemoprotection from malaria.

Polarization of MTIP is a signature of gliding locomotion in Plasmodium ookinetes and sporozoites

January 15, 2020 - 09:07 -- Open Access
Author(s): 
Siden-Kiamos I, Goosmann C, Buscaglia CA, Brinkmann V, Matuschewski K, Montagna GN
Reference: 
Molecular and Biochemical Parasitology, Volume 235, January 2020, 111247

Gliding motility and cell invasion are essential for the successful transmission of Plasmodium parasites. These processes rely on an acto-myosin motor located underneath the parasite plasma membrane. The Myosin A-tail interacting protein (MTIP) connects the class XIV myosin A (MyoA) to the gliding-associated proteins and is essential for assembly of the motor at the inner membrane complex.

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